Role of Derivatives Ciprofloxacin on Chronic Myeloid Leukemia: In Silico Approach

Introduction: chronic myeloid leukemia is one of the major diseases, which cause death worldwide. Tyrosine kinase responsible for uncontrolled cell growth and block its function. Its inhibition a promising route to control out grow cells. The purpose our study involves docking human Abl with seven ciprofloxacin derivatives comparison results free energy binding positive (Imatinib).Methods: present aims examine interactions between kinase(2HYY) domain retrieved from protein data bank in imatinib as reference. analysis was performed using Autodock vina Implicated PyRx 0.8 tool.Results: revealed that, according their still have lowest followed by CHOCP MPCP. In silico ADMET predictions that except DMOCP all other compounds had toxic effects.Conclusion: these may not serve potential inhibitor due high toxicity imatinib.